Ammonium in plasma

130.00 MDL

Order

Ammonium in Plasma

We remind you that independent interpretation of the results is unacceptable, the information provided below is for reference purposes only.

Ammonium (NH4+) is a cation that is produced as a waste product during the metabolism of proteins and other nitrogen-containing compounds in the body. It is primarily formed in the liver and then transported in the bloodstream to the kidneys, where it is excreted in urine.

Significance and Formation of Ammonium

Ammonium is a byproduct of the breakdown of amino acids, which are the building blocks of proteins. During this process, called deamination, the amino groups are removed from the amino acids, and ammonium is formed. The liver plays a crucial role in converting ammonium into urea, a less toxic compound, which is then filtered out by the kidneys and excreted in urine.

If the liver's ability to convert ammonium into urea is impaired, ammonium levels in the bloodstream can rise, leading to a condition known as hyperammonemia. This condition can be harmful and potentially life-threatening if left untreated.

Table 1: Sources of Ammonium Formation

Source	Description
Amino acid metabolism	Breakdown of amino acids releases ammonium.
Intestinal bacteria	Bacterial metabolism in the intestines produces ammonium.
Muscle breakdown	Breakdown of muscle proteins can release ammonium.

The measurement of ammonium levels in plasma can provide valuable information about liver function and the body's ability to metabolize and excrete nitrogenous waste products effectively.

The Role of Ammonium in Plasma

Ammonium levels in plasma play a crucial role in the diagnosis and monitoring of various metabolic disorders and liver diseases. Ammonia is a byproduct of protein metabolism, and its accumulation in the bloodstream can indicate an imbalance in the body's nitrogen cycle.

Indications for Ammonium in Plasma Testing

The ammonium in plasma test is typically recommended in the following situations:

Evaluation of liver function: Elevated ammonium levels can indicate liver dysfunction, as the liver is responsible for converting ammonia into urea for excretion.
Monitoring of hepatic encephalopathy: Hepatic encephalopathy is a neurological complication associated with liver disease, and ammonia toxicity is believed to be a contributing factor. Ammonium levels are monitored to assess the severity of this condition.
Diagnosis of inborn errors of metabolism: Certain genetic disorders, such as urea cycle defects, can lead to an accumulation of ammonia in the body, necessitating ammonium testing for diagnosis and management.
Assessment of kidney function: Impaired kidney function can also lead to elevated ammonium levels, as the kidneys play a role in excreting excess ammonia from the body.

Preparation for the Ammonium in Plasma Analysis Procedure

The procedure for drawing blood to determine the ammonium level in plasma requires some preparation. Here are a few recommendations to consider:

Dietary Regimen: In most cases, the ammonium in plasma analysis can be done after fasting or after a meal. However, in some situations (e.g., during a comprehensive biochemical blood analysis), an 8-12 hour fast before the blood draw may be required.
Avoiding Physical Exertion: Intense physical activity should be avoided on the day before the test, as it can affect the results.
Abstaining from Alcohol and Smoking: It is recommended to refrain from consuming alcohol and smoking for a day before the test, as these can influence the ammonium level and other blood parameters.
Maintaining Hydration: Adequate hydration is essential to facilitate the blood draw process. Dehydration can make the venipuncture procedure more difficult.
Informing the Doctor about Medications: Some medications can affect the ammonium level and other blood parameters. It is crucial to inform the doctor about any medications being taken.

Procedure for the Ammonium in Plasma Analysis

The blood draw for the ammonium in plasma analysis is typically performed from a vein in the antecubital fossa (inner elbow area). The procedure takes a few minutes and is carried out by a healthcare professional. After the venipuncture, minor bleeding or bruising may occur, which usually resolves on its own within a few days.

Sources:

https://healthmatters.io/understand-blood-test-results/ammonia-plasma
https://my.clevelandclinic.org/health/articles/22686-ammonia-levels
https://my.clevelandclinic.org/health/diseases/24065-hyperammonemia
https://www.labcorp.com/tests/007054/ammonia-plasma
https://www.mountsinai.org/health-library/tests/ammonia-blood-test
https://medlineplus.gov/lab-tests/ammonia-levels/
https://www.ncbi.nlm.nih.gov/books/NBK541039/

IMPORTANT!

It is essential to remember that the information provided in this section is not intended for self-diagnosis or self-treatment. If you experience any symptoms or a condition worsens, it is crucial to consult a healthcare professional for proper diagnosis and treatment. Only a qualified specialist can accurately diagnose and determine the appropriate course of action. For the most accurate and consistent evaluation of test results, it is recommended to have them performed at the same laboratory. This is because different laboratories may use varying methods and units of measurement for similar tests.

Notification

Add services