FibroMax (evaluation according to METAVIR system)

Fibromax (Evaluation According to Metavir System)

We remind you that independent interpretation of the results is unacceptable, the information provided below is for reference purposes only.

Fibromax is a non-invasive blood test used to assess the degree of liver fibrosis, which is the accumulation of scar tissue in the liver. The test evaluates the levels of various biomarkers in the blood, such as alpha-2-macroglobulin, haptoglobin, apolipoprotein A1, gamma-glutamyl transferase (GGT), total bilirubin, and alanine aminotransferase (ALT). These biomarkers are then analyzed using an algorithm to provide a score that corresponds to the stage of liver fibrosis according to the METAVIR scoring system.

METAVIR Scoring System

The METAVIR scoring system is a widely used classification system for grading the severity of liver fibrosis. It ranges from F0 (no fibrosis) to F4 (cirrhosis). The stages are as follows:

The Fibromax test provides a numerical score that correlates with the METAVIR staging system, allowing healthcare professionals to assess the level of liver fibrosis without the need for an invasive liver biopsy.

Role of Fibromax (Evaluation According to Metavir System)

The Fibromax test, also known as the Evaluation According to the Metavir System, is a non-invasive method used to assess the extent of liver fibrosis and inflammation in patients with chronic liver diseases, such as hepatitis C, hepatitis B, and non-alcoholic fatty liver disease (NAFLD). This test provides valuable information for monitoring the progression of liver disease and guiding appropriate treatment decisions.

Indications for Fibromax (Evaluation According to Metavir System)

The Fibromax test is typically recommended in the following situations:

• Diagnosis and staging of liver fibrosis: The test helps determine the severity of liver fibrosis, which is crucial for identifying patients at risk of developing cirrhosis or liver cancer.
• Monitoring of chronic liver diseases: Regular evaluation of liver fibrosis using the Fibromax test allows healthcare providers to monitor the progression or regression of liver disease and adjust treatment strategies accordingly.
• Evaluation of treatment response: The test can be used to assess the effectiveness of various treatments, such as antiviral therapy for hepatitis C or lifestyle modifications for NAFLD, by monitoring changes in liver fibrosis over time.
• Screening for liver disease: In certain high-risk populations, such as individuals with obesity, diabetes, or a history of excessive alcohol consumption, the Fibromax test may be recommended as a screening tool for early detection of liver fibrosis.

Preparation for the Procedure

The preparation for the Fibromax (Evaluation According To Metavir System) test is generally simple and does not require extensive measures. However, there are a few recommendations to consider:

• Dietary Adherence: In most cases, you can undergo the test with or without fasting. However, in some situations (e.g., comprehensive biochemical blood analysis), you may need to fast for 8-12 hours before the test.
• Avoiding Physical Exertion: It is advisable to avoid intense physical activities the day before the test, as they may affect the results.
• Abstaining from Alcohol and Smoking: Refrain from consuming alcohol and smoking for a day before the test, as they can influence the test results.
• Maintaining Hydration: Proper hydration is essential for facilitating the blood collection process. Inadequate fluid intake can make the venipuncture procedure more difficult.
• Informing about Medications: Inform your healthcare provider about any medications you are taking, as some drugs may affect the test results.

Procedure for Sample Collection

The blood sample for the Fibromax test is typically collected from a vein in the arm's bend. The procedure takes a few minutes and is performed by a healthcare professional. After the venipuncture, you may experience minor bleeding or bruising, which usually resolves on its own within a few days.

Turnaround Time

The turnaround time for the Fibromax test is typically 1 working day, excluding the day of sample collection.

Several factors can influence the test results, potentially causing inaccuracies or misinterpretations. Here are some factors to consider:

• Hydration Status: Dehydration may lead to an artificially elevated result due to decreased blood volume, while excessive fluid intake can dilute the sample and lower the result.
• Altitude: Living at high altitudes, where the air is thinner and has less oxygen, may stimulate the body to produce more red blood cells and influence the test results.
• Medications and Supplements: Certain medications and dietary supplements can affect the test results.
• Physical Activity: Intense physical exertion can temporarily alter the test results due to changes in blood flow and concentration.
• Nutrition: Inadequate intake of nutrients essential for proper liver function, such as vitamins and minerals, may impact the test results.
• Timing and Laboratory Conditions: Test results may vary slightly throughout the day, and adherence to laboratory standards is crucial for accurate results.

Fibromax (Evaluation According to Metavir System)

Fibromax is a non-invasive test used to assess the degree of liver fibrosis in patients with chronic liver disease. It is based on the Metavir scoring system, which is a histological classification system for staging liver fibrosis. The Fibromax test combines the measurement of several biomarkers, including alpha-2-macroglobulin, haptoglobin, apolipoprotein A1, gamma-glutamyl transferase (GGT), and total bilirubin, along with the patient's age and gender.

The Fibromax test provides a score that correlates with the Metavir stage of liver fibrosis, ranging from F0 (no fibrosis) to F4 (cirrhosis). It is an alternative to liver biopsy, which is an invasive procedure and can be associated with risks and complications. Fibromax is particularly useful for monitoring the progression of liver fibrosis over time and assessing the response to treatment.

Sources:

https://radiopaedia.org/articles/metavir-score-1
https://pubmed.ncbi.nlm.nih.gov/24646187/
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-15-76
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243934/

IMPORTANT!

It is crucial to remember that the information provided in this section is not intended for self-diagnosis or self-treatment. If you experience any pain or exacerbation of a condition, it is essential to consult a doctor for proper diagnostic tests and treatment. Only a qualified healthcare professional can make an accurate diagnosis and determine the appropriate course of action. To ensure consistent and accurate evaluation of test results, it is recommended to have your tests performed at the same laboratory, as different laboratories may use varying methods and units of measurement for similar tests.