Antibodies to HDV, Anti-HDV, IgM

Anti-HDV (Hepatitis Delta Virus Antibody)

We remind you that independent interpretation of the results is unacceptable, the information provided below is for reference purposes only.

Hepatitis Delta Virus (HDV) is a small, defective RNA virus that requires the presence of Hepatitis B Virus (HBV) for its replication and survival. HDV can only infect individuals who are already infected with HBV, leading to a more severe form of viral hepatitis known as Hepatitis D.

Structure and Transmission

The HDV genome consists of a single-stranded, circular RNA molecule enclosed within a protein coat. The virus cannot replicate on its own and relies on the Hepatitis B Virus for its replication and transmission. HDV is transmitted through exposure to infected blood or bodily fluids, similar to HBV.

The presence of anti-HDV antibodies in the blood indicates a current or past infection with the Hepatitis Delta Virus. HDV infection can lead to severe liver damage and complications, including cirrhosis and liver failure.

Role of Anti-HDV in Diagnostics

Anti-HDV, or antibodies against the hepatitis D virus (HDV), play a crucial role in the diagnosis of HDV infection. HDV is a defective virus that requires the presence of the hepatitis B virus (HBV) for its replication and survival. Anti-HDV antibodies are produced by the body's immune system in response to HDV infection.

Indications for Anti-HDV Testing

Anti-HDV testing is recommended in the following situations:

• Diagnosis of HDV infection: Anti-HDV testing is performed to detect the presence of HDV antibodies, which indicates an active or past HDV infection. This is particularly important for individuals who are also infected with HBV, as HDV can lead to more severe liver disease.
• Monitoring in chronic hepatitis B patients: Individuals with chronic HBV infection are at risk of acquiring HDV co-infection, which can worsen the course of the disease. Regular anti-HDV testing is recommended for monitoring and early detection of HDV co-infection.
• Evaluation of liver disease severity: The presence of HDV antibodies may indicate a more severe form of liver disease, as HDV can exacerbate the liver damage caused by HBV infection.
• Screening in high-risk populations: Anti-HDV testing may be recommended for individuals at high risk of HDV infection, such as intravenous drug users, individuals with multiple sexual partners, or those who have received blood or blood products from potentially infected sources.

Preparation for Anti-HDV Testing

Anti-HDV testing typically does not require any special preparation. However, it is recommended to inform your healthcare provider about any medications you are taking, as some drugs may potentially interfere with the test results.

Testing Procedure

Anti-HDV testing is performed by drawing a small sample of blood, usually from a vein in the arm. The blood sample is then sent to a laboratory for analysis. The procedure is relatively quick and straightforward.

Sources:

https://pubmed.ncbi.nlm.nih.gov/25072849/
https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.1890330412
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/hepatitis-delta-virus

IMPORTANT!

It is crucial to remember that the information provided in this section is not intended for self-diagnosis or self-treatment. If you experience any symptoms or a flare-up of a condition, it is essential to consult a healthcare professional for proper diagnostic tests and appropriate treatment. Only a qualified specialist can provide an accurate diagnosis and determine the appropriate course of treatment. To ensure the most accurate and consistent evaluation of test results, it is recommended to have them performed at the same laboratory, as different laboratories may use varying methods and units of measurement for similar tests.