Sumar antibodies to nuclear antigen of HBV, Anti-HBc, IgM/G
Anti-HBc
We remind you that independent interpretation of the results is unacceptable, the information provided below is for reference purposes only.
Anti-HBc, or hepatitis B core antibody, is a type of antibody produced by the body in response to exposure to the hepatitis B virus (HBV). It is directed against the core antigen (HBcAg), which is the internal component of the HBV viral particle. Anti-HBc can be of two types: IgM and IgG.
Types and Significance of Anti-HBc
Anti-HBc IgM: This type of antibody is produced during an acute or recent HBV infection. Its presence indicates an active or recent infection with the hepatitis B virus.
Anti-HBc IgG: This type of antibody develops after the acute phase of the infection and remains detectable for life in individuals who have recovered from HBV infection or have developed immunity through vaccination.
The presence of anti-HBc, particularly the IgG type, is a reliable marker of previous or ongoing HBV infection. However, it does not indicate whether the infection is active or resolved.
Component | Description |
---|---|
Globin | A protein portion consisting of four polypeptide chains |
Heme | A complex containing protoporphyrin and an iron ion, responsible for oxygen binding |
Anti-HBc testing is often used in combination with other hepatitis B markers, such as HBsAg (hepatitis B surface antigen) and anti-HBs (hepatitis B surface antibody), to determine the current or past infection status and the need for further testing or treatment.
Role of Anti-HBc in Diagnosis
Anti-HBc (Hepatitis B core antibody) is a blood test that detects antibodies against the core antigen of the Hepatitis B virus (HBV). The presence of Anti-HBc indicates previous or ongoing HBV infection. This test plays a crucial role in diagnosing and determining the stage of Hepatitis B infection.
Indications for Ordering the Test
The Anti-HBc test may be ordered in the following situations:
- Screening for Hepatitis B infection, particularly in high-risk populations or before certain medical procedures.
- Differentiating between acute and chronic Hepatitis B infection when combined with other HBV markers.
- Monitoring the immune response to Hepatitis B vaccination, as Anti-HBc can indicate natural exposure or vaccination.
- Evaluating individuals with abnormal liver function tests or suspected liver disease.
- Screening blood and organ donors for Hepatitis B infection.
Preparation for the Procedure
Preparing for an Anti-HBc test is relatively simple and does not require extensive measures. However, there are a few recommendations to consider:
- Fasting: In most cases, you can undergo the Anti-HBc test without fasting. However, if the test is part of a comprehensive blood panel, your healthcare provider may recommend fasting for 8-12 hours before the test.
- Avoiding physical exertion: Intense physical activity should be avoided on the day before the test, as it may affect the results.
- Abstaining from alcohol and smoking: It is advisable to refrain from consuming alcohol and smoking for at least 24 hours before the test, as these activities can potentially influence the test results.
- Maintaining hydration: Proper hydration is important to facilitate the blood draw process. Dehydration can make it more difficult to locate a suitable vein for the blood sample.
- Informing about medications: Certain medications can affect the results of the Anti-HBc test. Be sure to inform your healthcare provider about any medications you are currently taking.
Procedure for the Test
The Anti-HBc test involves drawing a small amount of blood from a vein, typically in the arm. The procedure is performed by a trained medical professional and takes only a few minutes. After the blood draw, you may experience minor bleeding or bruising at the site, which should resolve on its own within a few days.
Sources:
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/hepatitis-b-core-antigen
https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=hepatitis_b_core_antibody
https://www.mayoclinicproceedings.org/article/S0025-6196(12)64954-4/fulltext
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1549741/
IMPORTANT!
It is crucial to remember that the information provided in this section is not intended for self-diagnosis or self-treatment. If you experience any discomfort or exacerbation of symptoms, it is essential to consult a healthcare professional for proper diagnostic tests and appropriate treatment. Only a qualified specialist can provide an accurate diagnosis and determine the appropriate course of action. To obtain the most accurate and consistent evaluation of test results, it is recommended to conduct them at the same laboratory. This is because different laboratories may use varying methods and units of measurement for similar tests.