Dermatophagoides farinae, D2

House dust mites (HDMs) are the most important causes of allergic sensitization and allergic disease, including Dermatophagoides farinae as one of the principal species. Mites dominate in environments with temperate climates, damp, and humid dwellings. The HDM fecal pellets are reported to be the major source of allergens causing allergic reactions after inhalation. Mite allergens can trigger the symptoms in a sensitized individual through inhalation, ingestion and direct contact. Out of all the D. farinae allergens listed, Der f 1, Der f 2, Der f 11 and Der f 23 are the major allergens. A high degree of cross-reactivity is noted between D. pteronyssinus and D. farinae extracts, whereas the reactivity between Dermatophagoides and Blomia tropicalis is limited. Furthermore, a high degree of cross-reactivity is also observed between Der p 1 and Der f 1, Der p 2 and Der f 2, and between Der f 23 and Der p 23. Tropomyosins play an important role in the cross-reactivity. It has been reported that tropomyosin allergens from HDMs cross-react with crustaceans (shrimp, lobster, crab, crayfish) and mollusks (mussel, oyster, scallop, clams, abalone, snails, squid, octopus, cuttlefish). Furthermore, Der f 10 is found to be cross-reactive with Blo t 10, Lep d 10, Pen a 1, Per a 7 and Hom a 1.
Globally, house dust mites (HDMs) are the most important causes of allergic sensitization and allergic diseases. 

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