Immunoglobulin E, IgE total
1 day 
Available with home visit IgE Total
We remind you that independent interpretation of the results is unacceptable, the information provided below is for reference purposes only.
Immunoglobulin E (IgE) is an antibody produced by the immune system. It plays a crucial role in allergic reactions by recognizing and binding to specific allergens, such as pollen, dust mites, or certain foods. The total IgE test measures the overall level of IgE in the blood, which can provide insights into the presence and severity of allergies or certain immune system disorders.
Structure and Functions of IgE
IgE is a Y-shaped protein molecule composed of two identical heavy chains and two identical light chains. Each IgE molecule has two antigen-binding sites that can recognize and bind to specific allergens. When an allergen binds to IgE molecules attached to mast cells or basophils, it triggers the release of inflammatory mediators, such as histamine, which cause allergic symptoms like sneezing, itching, and swelling.
Table 1: IgE Antibody Structure
| Component | Description |
|---|---|
| Heavy Chains | Consist of constant and variable regions, responsible for antigen binding and effector functions. |
| Light Chains | Also contain constant and variable regions, contributing to antigen binding. |
| Antigen-Binding Sites | Formed by the variable regions of heavy and light chains, allowing specific recognition of allergens. |
The IgE antibody plays a crucial role in the body's defense against parasitic infections and in regulating immune responses to certain allergens. However, excessive production of IgE can lead to allergic disorders, such as asthma, eczema, and anaphylaxis.
The Role of Total IgE
Total IgE measurement is an important diagnostic tool in identifying and managing allergic conditions. IgE (Immunoglobulin E) is a type of antibody produced by the immune system in response to allergens. Elevated levels of total IgE can indicate an increased risk of allergic reactions or atopic diseases.
Indications for Total IgE Testing
Total IgE testing is recommended in the following situations:
- Evaluation of allergic disorders: Total IgE levels can help diagnose and monitor the severity of allergic conditions such as asthma, hay fever, food allergies, and atopic dermatitis.
- Screening for allergic predisposition: Individuals with a family history of allergic diseases or those at risk of developing allergies may benefit from total IgE testing.
- Monitoring treatment response: Total IgE levels can be useful in assessing the effectiveness of allergy treatments, such as immunotherapy or anti-IgE medications.
- Identifying potential allergens: In combination with specific IgE tests, total IgE levels can assist in identifying potential allergens contributing to an individual's allergic symptoms.
Preparation for the Test
Prior to taking the IgE Total test, several preparations are recommended:
- No specific dietary restrictions are required for this test. You can take it with or without fasting.
- Avoid strenuous physical activities for 24 hours before the test, as it may affect the results.
- Refrain from smoking and consuming alcohol at least 24 hours before the test.
- Stay well-hydrated to facilitate the blood draw process.
- Inform your healthcare provider about any medications you are taking, as some may influence the test results.
Test Procedure
The IgE Total test involves a simple blood draw, typically from a vein in the arm. The procedure is performed by a trained healthcare professional and takes only a few minutes. You may experience minor bleeding or bruising at the puncture site, which should resolve within a few days.
Calculation and Importance
The IgE Total test is a blood test that measures the total level of Immunoglobulin E (IgE) in the body. IgE is an antibody produced by the immune system in response to allergens or foreign substances. The test can be performed as part of an allergy evaluation or to monitor certain conditions involving the immune system.
The IgE Total test is often included in a comprehensive allergy panel or ordered along with other tests to help diagnose and manage allergic conditions. It provides valuable information about the overall IgE levels, which can be elevated in individuals with allergies or certain immune disorders.
Sources:
https://medlineplus.gov/lab-tests/allergy-blood-test/
https://dermnetnz.org/topics/immunoglobulin-e-tests
https://my.clevelandclinic.org/health/treatments/22345-allergy-blood-test
https://labs.selfdecode.com/blog/immunoglobulin-e-ige-antibody-test/
https://www.verywellhealth.com/ige-test-overview-6362110
https://www.testing.com/tests/total-ige/
https://www.verywellhealth.com/immunoglobulin-e-ige-5324765
IMPORTANT!
It's crucial to remember that the information provided here is not intended for self-diagnosis or self-treatment. If you experience any symptoms or have a medical condition, it's essential to consult a qualified healthcare professional for proper diagnosis and treatment. Only a licensed physician can make an accurate diagnosis and recommend appropriate treatment. For consistent and accurate evaluation of test results, it's recommended to have the tests performed at the same laboratory, as different laboratories may use varying methods and units of measurement for similar tests.
