Parathyroid hormone, intact, PTH

Parathyroid Hormone (PTH)

We remind you that independent interpretation of the results is unacceptable, the information provided below is for reference purposes only.

Parathyroid hormone (PTH) is a crucial hormone produced by the parathyroid glands, which are small endocrine glands located in the neck, near the thyroid gland. PTH plays a vital role in regulating calcium and phosphate levels in the body, maintaining the balance necessary for proper bone formation and overall mineral homeostasis.

Structure and Functions of PTH

PTH is a single-chain polypeptide hormone consisting of 84 amino acids. Its primary function is to increase the concentration of calcium in the blood by acting on various target organs and tissues. PTH achieves this through the following mechanisms:

PTH also plays a role in the regulation of bone remodeling, a continuous process in which old bone tissue is removed and replaced with new bone tissue. This process is essential for maintaining healthy bone structure and strength.

The Role of PTH

Parathyroid hormone (PTH) plays a crucial role in regulating calcium and phosphate homeostasis in the body. It is produced by the parathyroid glands and helps maintain appropriate levels of these minerals in the blood and bones.

Indications for PTH Testing

PTH testing is often ordered to evaluate and diagnose disorders related to calcium and phosphate metabolism, including:

• Hypoparathyroidism: A condition characterized by low PTH levels, which can lead to low calcium and high phosphate levels in the blood.
• Hyperparathyroidism: A disorder marked by excessive PTH production, often resulting in high calcium and low phosphate levels.
• Chronic kidney disease: Impaired kidney function can lead to abnormal PTH levels and disruption of calcium and phosphate balance.
• Osteoporosis: PTH testing may be useful in evaluating bone metabolism and the risk of osteoporosis.
• Monitoring of calcium and phosphate levels: PTH testing can help assess the effectiveness of treatments aimed at maintaining normal calcium and phosphate levels.

Preparation for the PTH Test

The procedure for giving blood to determine the PTH level is relatively simple and does not require special preparation measures. However, there are several recommendations that should be considered:

• Dietary regimen: In most cases, the PTH blood test can be taken either fasting or after eating. However, in some situations (e.g., during a comprehensive biochemical blood analysis), an 8-12 hour fast before blood collection may be required.
• Avoiding physical exertion: Before the examination, intense physical activity should be avoided, as it can affect the test results.
• Avoiding alcohol and smoking: On the day before the test, it is recommended to abstain from consuming alcohol and smoking, as these can affect the PTH level and other blood parameters.
• Maintaining hydration: Maintaining proper hydration is important to facilitate the blood collection procedure. Inadequate fluid intake can make the venipuncture procedure more difficult.
• Informing the doctor about medications: Some medications can affect the PTH level and other blood parameters. Therefore, it is essential to inform the doctor about all medications being taken.

Test Procedure

Blood collection for the PTH test is usually performed from a vein located at the elbow crease. The procedure takes a few minutes and is performed by a healthcare professional. After venipuncture, minor bleeding or bruising may occur, which typically resolves on its own within a few days.

Sources:

https://www.webmd.com/a-to-z-guides/parathyroid-hormone-blood-test
https://en.wikipedia.org/wiki/Parathyroid_hormone
https://www.mayoclinic.org/diseases-conditions/hyperparathyroidism/symptoms-causes/syc-20356194
https://my.clevelandclinic.org/health/body/parathyroid-gland
https://www.ncbi.nlm.nih.gov/books/NBK499940/
https://my.clevelandclinic.org/health/articles/22355-parathyroid-hormone

IMPORTANT!

It is crucial to remember that the information provided here is not intended for self-diagnosis or self-treatment. If you are experiencing any symptoms or have a worsening condition, it is essential to consult a healthcare professional for proper diagnostic testing and treatment recommendations. Only a qualified specialist can provide an accurate diagnosis and determine the appropriate treatment plan. To ensure consistency and accuracy in interpreting test results, it is recommended to have tests performed at the same laboratory, as different laboratories may use varying methods and units of measurement for similar tests.