Protein (24h urine test)

We remind you that independent interpretation of the results is unacceptable, the information provided below is for reference purposes only.

Proteinuria is a laboratory test that measures the total amount of protein excreted in urine over a 24-hour period. Normally, the kidneys prevent significant amounts of protein from passing into urine. Elevated protein levels may indicate kidney damage, impaired filtration function, or certain systemic diseases.

Indications

• suspected kidney disease
• chronic kidney disease
• nephrotic syndrome
• diabetes mellitus
• arterial hypertension
• edema of unclear origin
• monitoring kidney disease progression and treatment
• suspected pregnancy complications (preeclampsia)
• systemic autoimmune diseases
• comprehensive evaluation of kidney function

Procedure

• the test is performed using a 24-hour urine collection
• the first morning urine sample is not collected
• afterward, all urine passed during 24 hours is collected in a clean container
• the final portion is added the following morning at the same time the collection began
• after completion it is necessary to:
  • measure and record the total urine volume
  • gently mix the contents of the container
  • transfer a small amount into a sterile container for laboratory testing
• during collection, the container should be stored in a cool place or refrigerator

Interpretation of Results

• Elevated protein level:
  • may indicate glomerular kidney damage
  • may occur in inflammatory kidney diseases
  • can be observed in diabetes mellitus and hypertension
  • may increase during infections, intense physical activity, or pregnancy
• Normal or low protein level:
  • usually indicates preserved kidney filtration function
  • should be interpreted together with other laboratory findings

Clinical Significance

• helps detect early signs of kidney damage
• used to monitor progression of kidney diseases
• important in patients with diabetes and hypertension
• used to assess the risk of pregnancy complications
• helps evaluate treatment effectiveness

Sources:

https://my.clevelandclinic.org/health/diagnostics/12983-urine-protein-test
https://www.mayoclinic.org/symptoms/protein-in-urine/basics/definition/sym-20050656
https://www.webmd.com/a-to-z-guides/proteinuria-protein-in-urine
https://medlineplus.gov/lab-tests/protein-in-urine/

IMPORTANT!

It is crucial to remember that the information provided in this section is not intended for self-diagnosis or self-treatment. If you experience any pain or exacerbation of symptoms, it is essential to consult a healthcare professional for proper diagnosis and treatment. Only a qualified specialist can accurately diagnose and determine the appropriate course of action. To ensure the most accurate and consistent assessment of test results, it is recommended to conduct tests at the same laboratory. This is because different laboratories may use varying methods and units of measurement for similar tests.