Free testosterone (calculated)

Free Testosterone (Calculated)

We remind you that independent interpretation of the results is unacceptable, the information provided below is for reference purposes only.

Free testosterone is the biologically active form of testosterone that is not bound to proteins in the blood, such as sex hormone-binding globulin (SHBG) and albumin. It represents the fraction of total testosterone that is available to interact with androgen receptors in target tissues and exert its physiological effects.

Functions and Significance of Free Testosterone

Free testosterone plays a crucial role in various physiological processes, including:

• Reproductive function and male sexual development
• Muscle growth and maintenance
• Bone density regulation
• Regulation of libido and sexual function
• Influencing mood and cognitive function

The measurement of free testosterone is important because it provides a better indication of the biologically active fraction of testosterone compared to total testosterone levels. This is particularly relevant in certain clinical conditions where total testosterone levels may not accurately reflect the androgen status.

Factors Affecting Free Testosterone Levels

Several factors can influence the levels of free testosterone, including:

It is important to note that the interpretation of free testosterone levels should be done in conjunction with other clinical findings and under the guidance of a qualified healthcare professional.

Role of Free Testosterone (Calculated) in Diagnosis

Free testosterone, also known as bioavailable testosterone, is the fraction of total testosterone that is not bound to proteins in the blood and is readily available for biological activity. Measuring free testosterone levels is essential for evaluating various hormonal imbalances and conditions related to androgen deficiency or excess.

Indications for Ordering the Test

The free testosterone (calculated) test is typically ordered in the following situations:

• Evaluation of male hypogonadism (low testosterone levels): Low free testosterone levels can cause symptoms such as decreased libido, erectile dysfunction, fatigue, and loss of muscle mass.
• Assessment of androgen disorders in women: Elevated levels of free testosterone in women can lead to conditions like polycystic ovarian syndrome (PCOS) and hirsutism (excessive hair growth).
• Monitoring testosterone replacement therapy: The test can help adjust the dosage of testosterone therapy to achieve optimal levels.
• Investigation of fertility issues: Both low and high levels of free testosterone can affect fertility in men and women.
• Evaluation of androgen-related disorders: Conditions like congenital adrenal hyperplasia, androgen-secreting tumors, and certain types of cancers may affect free testosterone levels.

It's important to interpret the results of the free testosterone (calculated) test in conjunction with other relevant clinical information and under the guidance of a qualified healthcare professional.

Preparation for the Free Testosterone (Calculated) Test

Preparing for the Free Testosterone (Calculated) test typically involves the following steps:

• Dietary considerations: In most cases, you can take the test without fasting. However, if you are undergoing a comprehensive blood panel, your healthcare provider may recommend fasting for 8-12 hours before the test.
• Avoid strenuous exercise: It's advisable to avoid intense physical activity on the day before the test, as it can temporarily affect hormone levels.
• Abstain from alcohol and smoking: Refrain from consuming alcohol and smoking for at least 24 hours before the test, as these activities can influence hormone levels.
• Maintain proper hydration: Ensure that you are well-hydrated before the test to facilitate easier blood collection.
• Inform your healthcare provider about medications: Certain medications, including hormonal therapies, can influence testosterone levels. Let your healthcare provider know about any medications you are taking.

Test Procedure

The Free Testosterone (Calculated) test involves drawing a small amount of blood, typically from a vein in your arm. The procedure is brief and performed by a trained healthcare professional. Some minor discomfort or bruising may occur at the puncture site, but this typically resolves quickly.

About the Free Testosterone (Calculated) Test

The free testosterone (calculated) test is a method used to determine the amount of testosterone that is not bound to proteins in the blood. It is calculated based on the measured levels of total testosterone, sex hormone-binding globulin (SHBG), and albumin. The free testosterone represents the biologically active fraction of testosterone that can readily enter cells and exert its effects on target tissues.

This test is often included as part of a comprehensive hormonal evaluation, particularly in the assessment of male reproductive function, sexual dysfunction, and certain endocrine disorders. It provides valuable information about the bioavailable testosterone levels, which can be helpful in diagnosing conditions related to testosterone deficiency or excess.

Sources:

https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=testosterone_free
https://www.medichecks.com/blogs/testosterone/what-s-the-difference-between-total-and-free-testosterone
https://www.webmd.com/a-to-z-guides/testosterone-test

ВАЖНО!

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