Prothrombin by Quick (activity), %
1 day 
Available with home visit Prothrombin activity according to Quick, % is a parameter derived from prothrombin time (PT), used to assess the function of the extrinsic and common pathways of blood coagulation.
Prothrombin activity according to Quick is expressed as a percentage, based on the relationship between the patient's clotting time and the calibration curve specific to the method and reagent used.
Purpose of the Test
- assessment of the extrinsic and common coagulation pathways;
- investigation of suspected hemostatic disorders;
- evaluation of coagulation abnormalities associated with vitamin K deficiency;
- assessment of impaired hepatic synthesis of coagulation factors;
- investigation of bleeding disorders;
- evaluation of patients in clinical situations where coagulopathy is suspected.
Indications
- spontaneous, unusual, or prolonged bleeding;
- unexplained bruising or hematomas;
- suspected coagulation factor deficiency;
- suspected vitamin K deficiency;
- acute or chronic liver diseases with possible impairment of hepatic synthetic function;
- suspected disseminated intravascular coagulation (DIC);
- assessment of coagulation disorders in an appropriate clinical context;
- preprocedural assessment in selected patients, depending on bleeding history, anticoagulant treatment, and the risk associated with the procedure.
Procedure
A venous blood sample is collected into a tube containing sodium citrate, ensuring the correct blood-to-anticoagulant ratio.
Sources:
https://www.ncbi.nlm.nih.gov/books/NBK544269/?report
https://pmc.ncbi.nlm.nih.gov/articles/PMC6559624/?utm
https://en.wikipedia.org/wiki/Prothrombin_time
https://www.sciencedirect.com/science/article/pii/S1538783626000528
Preparation:
No special preparation is generally required for this test.
The following is recommended:
- blood collection under baseline conditions, preferably in the morning if the test is scheduled;
- maintaining normal hydration with water;
- avoiding discontinuation of prescribed treatment without medical advice;
- informing the laboratory about anticoagulant therapy, particularly acenocoumarol or warfarin;
- reporting any other medications or supplements that may affect hemostasis or vitamin K metabolism;
- for patients taking vitamin K antagonists, the timing of blood collection should follow the physician's instructions and the monitoring protocol.
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