Thrombophilia Profile

The Thrombophilia Profile is a comprehensive laboratory panel designed to assess the risk of thrombophilia — an increased tendency for blood clot formation (thrombi). The panel includes genetic and biochemical markers involved in coagulation processes and folate metabolism, providing an integrated overview of factors influencing thrombotic risk.

This investigation is used both to identify inherited predisposition to thrombosis and to evaluate acquired risk factors associated with vascular and obstetric complications.

Indications

The profile is recommended for:

• patients with a personal history of venous or arterial thrombosis;
• individuals with a family history of thrombosis or thrombophilia;
• women with recurrent miscarriages, obstetric complications, or unexplained infertility;
• prior to initiation of hormonal therapy or oral contraceptives (upon medical indication);
• patients with thrombotic events at a young age;
• assessment of thrombotic risk before surgical interventions or other clinically relevant situations;
• upon referral from a hematologist, gynecologist, cardiologist, or other specialists.

Method of investigation (panel composition)

The panel includes assessment of:

• genetic factors associated with hereditary thrombophilia (genetic thrombophilia test — 8 polymorphisms);
• polymorphisms involved in folate metabolism (4 polymorphisms);
• homocysteine levels — a marker of thrombotic and cardiovascular risk;
• Antithrombin III activity;
• Free Protein S levels;
• Protein C levels (coagulation Protein C).

Procedure

The investigation involves venous blood sampling for biochemical and coagulation parameters, as well as genetic analysis of the collected material.

Limitations

Test results should be interpreted in a clinical context, taking into account the patient’s personal and family medical history.

Certain factors such as pregnancy, anticoagulant therapy, hormonal treatment, liver diseases, and inflammatory conditions may influence results and should be communicated to medical staff.