Human epididymis protein 4, HE4

He4

We remind you that independent interpretation of the results is unacceptable, the information provided below is for reference purposes only.

He4, also known as helium-4, is a stable isotope of the noble gas helium. It is the most abundant isotope of helium, making up approximately 99.999863% of naturally occurring helium on Earth. He4 is a remarkably stable and unreactive particle, and its unique properties have made it an essential element in various scientific and technological applications.

Structure and Properties of He4

He4 is a non-radioactive isotope with a stable nucleus consisting of two protons and two neutrons. Its atomic mass is approximately 4.0026 atomic mass units (u). Unlike many other atoms, He4 does not form compounds, as its outermost electron shell is complete, making it chemically inert.

He4 has unique physical properties, including an extremely low boiling point (-268.9°C or -452°F) and the lowest density of any known gas at standard temperature and pressure. These properties make He4 useful in various applications, such as cryogenics, superconductivity research, and low-temperature physics experiments.

The Role of He4 in Diagnostics

He4 (Human Epididymis Protein 4) is a protein found in various body fluids, including serum, and plays a crucial role in the diagnosis of certain medical conditions. Its levels can provide valuable insights into the presence and progression of diseases such as ovarian cancer.

Indications for He4 Testing

He4 testing is commonly ordered in the following situations:

• Ovarian cancer screening and diagnosis: Elevated levels of He4 are often observed in patients with ovarian cancer, particularly in its early stages. He4 testing, in combination with other markers and imaging techniques, can aid in the detection and monitoring of ovarian cancer.
• Monitoring response to treatment: He4 levels can be monitored during and after treatment for ovarian cancer to assess the effectiveness of therapy and detect any recurrence or progression of the disease.
• Differential diagnosis: He4 testing may help distinguish ovarian cancer from other gynecological conditions, such as endometriosis or pelvic inflammatory disease.

Preparation for the Test Procedure

The preparation for the He4 test is relatively simple and does not require any special measures. However, there are a few recommendations to consider:

• Dietary Regimen: In most cases, the He4 test can be taken both on an empty stomach or after a meal. However, in certain situations (e.g., during a comprehensive biochemical blood analysis), an 8-12 hour fast before the blood draw may be required.
• Avoiding Physical Exertion: It is advisable to avoid intense physical activity on the day before the test, as it may affect the results.
• Abstaining from Alcohol and Smoking: It is recommended to refrain from consuming alcohol and smoking on the day before the test, as these activities can influence the He4 levels and other blood markers.
• Maintaining Hydration: Proper hydration is important to facilitate the blood draw procedure. Inadequate fluid intake can make the venipuncture process more challenging.
• Informing the Physician about Medications: Some medications can affect the He4 levels and other blood markers. It is crucial to inform the physician about all medications taken.

Test Procedure

The He4 test typically involves drawing blood from a vein in the arm, usually at the elbow crease. The procedure takes a few minutes and is performed by a medical professional. After the venipuncture, minor bleeding or bruising may occur, which typically resolves within a few days.

Sources:

https://www.mayocliniclabs.com/test-catalog/Overview/62137
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987291/
https://www.labcorp.com/tests/081700/human-epididymis-protein-4
https://www.nature.com/articles/s41598-020-79960-1
https://www.sciencedirect.com/topics/medicine-and-dentistry/human-epididymis-protein-4
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629466/
https://www.testing.com/tests/human-epididymis-protein-4-he4/

IMPORTANT!

It is crucial to remember that the information provided in this section is not intended for self-diagnosis or self-treatment. If you experience any pain or exacerbation of a condition, it is essential to consult a healthcare professional for proper diagnosis and treatment. Only a qualified specialist can accurately diagnose and determine the appropriate course of action. To ensure the most accurate and consistent evaluation of test results, it is recommended to have them performed at the same laboratory, as different laboratories may use varying methods and units of measurement for similar tests.