N-terminal pro-brain natriuretic peptide, pro-B-type natriuretic peptide, NT-proBNP

NT-proBNP

We remind you that independent interpretation of the results is unacceptable, the information provided below is for reference purposes only.

NT-proBNP, short for N-terminal pro-B-type natriuretic peptide, is a biomarker that is released into the bloodstream by the heart. It is a fragment of the proBNP molecule, which is synthesized and released primarily by the ventricular myocardium (the muscular walls of the ventricles) in response to increased strain or stretch.

Structure and Function of NT-proBNP

NT-proBNP is a byproduct of the cleavage of proBNP into the active hormone BNP (B-type natriuretic peptide) and the inactive NT-proBNP fragment. BNP plays a crucial role in regulating blood pressure, fluid balance, and cardiovascular homeostasis by promoting natriuresis (excretion of sodium and water) and vasodilation (widening of blood vessels).

While NT-proBNP itself does not have direct biological activity, its levels in the bloodstream correlate with the levels of BNP and the degree of cardiac stress or dysfunction. Therefore, NT-proBNP is used as a diagnostic marker for various cardiovascular conditions, particularly heart failure.

NT-proBNP levels are typically elevated in conditions that lead to increased stress or strain on the heart, such as heart failure, coronary artery disease, myocardial infarction (heart attack), and certain forms of valvular heart disease. Measuring NT-proBNP levels can aid in the diagnosis, risk stratification, and monitoring of these conditions.

Role of NT-proBNP

NT-proBNP (N-terminal pro-B-type natriuretic peptide) is a biomarker that plays a crucial role in the diagnosis and management of heart failure. It is a fragment of the proBNP molecule, which is released from the heart in response to increased pressure or strain on the heart muscle.

Indications for NT-proBNP Testing

The NT-proBNP test is typically ordered in the following situations:

• Diagnosis of heart failure: Elevated levels of NT-proBNP can help diagnose heart failure, especially in individuals with symptoms such as shortness of breath, fatigue, and swelling.
• Monitoring heart failure treatment: NT-proBNP levels can be used to monitor the effectiveness of heart failure treatment and guide medication adjustments.
• Evaluation of dyspnea (shortness of breath): High levels of NT-proBNP can indicate that dyspnea is caused by heart failure, rather than other conditions like lung disease.
• Risk assessment for cardiovascular events: Elevated NT-proBNP levels may indicate an increased risk for future cardiovascular events, such as heart attacks or stroke.

Preparation for the Procedure

Preparing for the NT-proBNP test is relatively simple and does not require any special measures. However, there are a few recommendations to keep in mind:

• Fasting: The NT-proBNP test can typically be performed whether you are fasting or not. However, in some cases (e.g., during a comprehensive blood test), you may be asked to fast for 8-12 hours before the test.
• Avoid physical exertion: It is recommended to avoid intense physical activity before the test, as it may affect the results.
• Abstain from alcohol and smoking: Refrain from consuming alcohol and smoking for at least 24 hours before the test, as these activities may influence the NT-proBNP levels and other blood parameters.
• Hydration: Maintain proper hydration levels to facilitate the blood draw process. Dehydration can make it more difficult to locate a vein for the procedure.
• Inform about medications: Certain medications can affect the NT-proBNP levels and other blood parameters. Be sure to inform your healthcare provider about any medications you are taking.

Procedure for Sample Collection

The blood sample for the NT-proBNP test is typically drawn from a vein in the arm, usually in the area of the inner elbow. The procedure takes only a few minutes and is performed by a trained medical professional. After the blood draw, you may experience minor bleeding or bruising at the puncture site, which should resolve on its own within a few days.

NT-proBNP Test

The NT-proBNP test is a blood test that measures the level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in the blood. NT-proBNP is a hormone produced by the heart muscles in response to increased strain or stress on the heart. The test is typically ordered as part of a comprehensive evaluation for heart failure or other cardiovascular conditions.

The NT-proBNP test can be performed on a blood sample drawn from a vein. The sample is then analyzed in a laboratory, and the results are reported as a numerical value, typically in picograms per milliliter (pg/mL). Higher levels of NT-proBNP may indicate an increased risk or presence of heart failure, while lower levels are often associated with a lower risk.

Sources:

https://peptidesguide.com/natriuretic-peptides.html
https://www.webmd.com/heart-disease/heart-failure/bnp-blood-test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181765/
https://en.wikipedia.org/wiki/N-terminal_prohormone_of_brain_natriuretic_peptide
https://medlineplus.gov/lab-tests/natriuretic-peptide-tests-bnp-nt-probnp/
https://my.clevelandclinic.org/health/diagnostics/22629-b-type-natriuretic-peptide
https://academic.oup.com/eurheartj/article/26/21/2269/443429

IMPORTANT!

It is crucial to remember that the information provided in this section is not intended for self-diagnosis or self-treatment. If you experience any concerning symptoms or exacerbation of a condition, it is essential to consult a healthcare professional for proper diagnostic testing and treatment recommendations. Only a qualified specialist can provide an accurate diagnosis and appropriate treatment plan. To obtain the most accurate and consistent evaluation of test results, it is recommended to have them performed at the same laboratory, as different laboratories may use different methods and units of measurement for similar tests.